This paper used trade data with the year 2001-2018 to construct the global manufacturing multi-layer trade network, analyzed the characteristics of the network and predicted the development trend of the network. The results show that global manufacturing trade has been on the rise and focus on the increase of trade flow; trade be more likely to cooperate with core economic or trade organization; the orientation of returning to manufacturing makes a positive impact on manufacturing trade; network accessibility and compactness are strong, and it tends to be mature. Core-periphery analysis reveals that the United States and China will be the core countries of high, medium and low technology products. The trade forecast results show that the United States and China will conduct fierce manufacturing competition, and the world will form three manufacturing trade dominant regions of North American three countries, Asia-pacific cluster and European cluster.