With the increasing expansion of urban scale and the gradual upgrading of industrial structure, the urbanization level has been continuously promoted. Only by industry and space coordinated development, can the economy be developed rapidly and reasonably, and the quality of urbanization be improved. In recent years, the economic development of central plains urban agglomeration is growing rapidly. However, it is precisely because the central plains urban agglomeration is pursuing the rapid development of the economy, and it has gradually formed a kind of development mode. In this paper, in constructing the index system of urban space and industrial development, using the entropy weight method and the methods of coupling coordination degree model, the measure of central plains urban agglomeration spatial and industrial comprehensive development level and the coupling coordination degree, the results show that most cities are in dissonance. Using vertical analysis, the results show that the spatial pattern centered on Zhengzhou has gradually evolved from the spatial point of view. From the perspective of time series, the urban agglomeration of central plain, the industry is evolving in the fluctuation; the main changes are affected by economic environment and policy. Therefore, several suggestions are proposed for these problems, such as accelerating the industrial upgrading and innovation, scientific distribution and rational use of land, and establishing an innovative mechanism for the coordinated development of industry and space