This qualitative research is a case study focusing on leadership style and how leaders in School of Education Science, Nanjing Normal University (SES, NNU), carry out their leadership. Interview method is used for the study with 5 questions, 1) What are your major responsibilities? 2) What do you look for when you observe subordinates? 3) What are some ways you provide to support for subordinates? 4) What would you say are the most pressing issues that you are deliberating on now? 5) How would you describe your leadership style? Respondents in this study are two leaders in SES, NNU. The theory of the organizational frame by Bolman and Deal (2008) is used to analyze the response and date I have collected. By study, I want to see, 1) How the leaders in SES, NNU make sense of their organization, 2) How they apply their leadership into practice leadership according to the character of their organizational situations, 3) What implication we can have to our practice? I find that two leaders understand SES and its staff. They carry out their leadership in perspective of structural frame mainly and show some skills for political frame and that of human resources as well. Their practice implies us that organization frame provides a foundation for leadership style. What’s more, organizational analysis, tacit understanding of the organization, appropriate measures, harmonious relationship and positive role by leaders and subheads are important for effective and efficient leadership.